Gilles Plourde, MD, MSc
Outre de fournir des soins cliniques en anesth茅sie, j鈥檈ffectue de la recherche pour comprendre comment les anesth茅siques g茅n茅raux causent un 茅tat d鈥檌nconscience. Bien qu鈥檜tilis茅s depuis plus de 150 ans, leurs m茅canismes d鈥檃ction restent obscurs. J鈥檃i recours 脿 des 茅tudes 茅lectrophysiologiques (EEG ou potentiels 茅voqu茅s sensoriels) chez des sujets humains et des animaux, ou 脿 des 茅tudes d鈥檌magerie c茅r茅brale fonctionnelle (TEP ou IRMf) chez des sujets humains. Un 茅l茅ment cl茅 de mes recherches est l鈥檜tilisation de m茅thodes d鈥檃dministration d鈥檃gents anesth茅siques permettant de contr么ler avec pr茅cision leur concentration dans le sang.
Plourde G, Arsenau F Attenuation of High-Frequency (30-200 Hz) Thalamocortical EEG Rhythms as Correlate of Anaesthetic Action: Evidence from Dexmedetomidine , Br J Anaesth, 119:1150鈥�60, 2017 doi: 10.1093/bja/aex329
Reed SJ, Plourde G Attenuation of high-frequency (50-200 Hz) thalamocortical EEG rhythms by propofol in rats is more pronounced to the thalamus than for the cortex, 2015, PLoS ONE 10(4): e0123287. doi:10.1371/journal.pone.0123287
Verdonck, O, Reed SJ, Hall J, Gotman J, Plourde G The sensory thalamus and cerebral motor cortex are affected concurrently during induction of anesthesia with propofol - a case series with intracranial EEG recordings. Can J Anesth. 61:254-62, 2014. doi: 10.1007/s12630-013-0100-y. Epub 2014 Jan 22
Reed SJ, Plourde G, Tobin S and Chapman, CA Partial antagonism of proprofol anesthesia by physostigmine in rats is associated with potentiation of fast (80-200 Hz) oscillations in the thalamus, Br J Anaesthesia, 110:646鈥�53, 2013 doi:10.1093/bja/aes432
Xie G, Deschamps A, Backman SB, Fiset P, Chartrand D, Dagher A, Plourde G. Critical involvement of the thalamus and precuneus during restoration of consciousness with physostigmine in humans during propofol anaesthesia: a positron emission tomography study, Br J Anaesthesia, 106:548-57, 2011
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