Ã山ǿ¼é

Daniel J. Bernard

Daniel J. Bernard, Ph.D.

Professor, Department of Pharmacology and Therapeutics
Director, Centre for the Study of Reproduction
Department of Anatomy and Cell Biology
Department of Physiology
3655 Promenade Sir William Osler, room 1320

Tel: 514-398-2525

daniel.bernard [at] mcgill.ca
Website

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Biographical Sketch

Prof. Bernard earned his Ph.D. at Johns Hopkins University and then conducted post-doctoral research in molecular endocrinology at Northwestern University. His first independent position was as a Staff Scientist at the Population Council’s Center for Biomedical Research at The Rockefeller University. He then moved his lab to Ã山ǿ¼é in April 2006.ÌýÌý

Keywords

Pituitary, neuroendocrinology, reproductive biology, signal transduction, transcription, mouse genetics, cell cultureÌý

Research or Clinical Activities

TheÌýBernardÌýlab investigates molecular mechanisms of pituitary hormone synthesis and action using in vitro and in vivo approaches. Projects in the lab concern: 1) signal transduction mechanisms through which members of the transforming growth factor β superfamily regulate pituitary follicle-stimulating hormone (FSH) synthesis, 2) mechanisms of gonadotropin-releasing hormone (GnRH) signaling in pituitary gonadotrope cells, 3) extragonadal actions of FSH, and 4) hypothalamic-pituitary control of thyroid hormone production.

Selected Recent Publications

Sun Y, Bak B, Schoenmakers N, van Trotsenburg AS, Oostdijk W, Voshol P, Cambridge E, White JK, le Tissier P, Gharavy SN, Martinez-Barbera JP, Stokvis-Brantsma WH, Vulsma T, Kempers MJ, Persani L, Campi I, Bonomi M, Beck-Peccoz P, Zhu H, Davis TM, Hokken-Koelega AC, Del Blanco DG, Rangasami JJ, Ruivenkamp CA, Laros JF, Kriek M, Kant SG, Bosch CA, Biermasz NR, Appelman-Dijkstra NM, Corssmit EP, Hovens GC, Pereira AM, Dunnen JT, Wade MG, Breuning MH, Hennekam RC, Chatterjee K, Dattani MT, Wit JM,ÌýBernardÌýDJÌý(2012)ÌýÌýNature GeneticsÌý44(12):1375-1381.Ìý

Toufaily C, Fortin J, Alonso CAI, Lapointe E, Zhou X, Santiago-Andres Y, Lin Y-F,ÌýCui Y,ÌýWang Y, Devost D, Roelfsema F, Steyn F, Hanyaloglu AC, Hébert TE, Fiordelisio T, Boerboom D,ÌýBernardÌýDJÌý(2021)ÌýÌýeLife,Ìý10:e72937.

Ruf-Zamojski F, Zhang Z, Zamojski, Smith GR, Mendelev N, Liu H, Nudelman G, Moriwaki M, Pincas H, Castanon RG, Nair VD, Seenarine N, Amper MAS, Zhou X, Ongaro L, Toufaily C, Schang G, Nery JR, Bartlett A, Aldridge A, Jain N, Childs GV, Troyanskaya OG, Ecker JR, Turgeon JL, Welt CK,ÌýBernardÌýDJ, Sealfon SC (2021) ÌýNature CommunicationsÌý12:Ìý2677.

Brûlé E, Wang Y, Li Y, Lin Y-F, Zhou X, Ongaro L, Alonso CAI, Buddle ERS, Schneyer AL, Byeon C-H, Hinck CS, Mendelev N, Russell JP, Cowan M, Boehm U, Ruf-Zamojski F, Zamojski M, Andoniadou CL, Sealfon SC, Harrison CA, Walton KL, Hinck AP,ÌýBernardÌýDJÌý(2021) ÌýScience AdvancesÌý7(51): eabl4391.Ìý

PubMed Publications –

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