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Publications

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The following is a list of the joint publications from collaborations betweenÌýCFTRc Members since 2014.

Ìý


2023

116.ÌýGauvreau A, Carrier FM, Poirier C, Morisset J, Lands LC, Lavoie A, Nasir B, Ferraro P, Luong ML. 2023 . J Heart Lung Transplant. S1053-2498(23)00040-2. doi: 10.1016/j.healun.2023.02.001.

117. Pernet E, Sun S, Sarden N, Gona S, Nguyen A, Khan N, Mawhinney M, Tran KA, Chronopoulos J, Amberkar D, Sadeghi M, Grant A, Wali S, Prevel R, Ding J, Martin JG, Thanabalasuriar A, Yipp BG, Barreiro LB, Divangahi M. 2023 . Nature. 614(7948):530-538.

118.ÌýSato Y, Kim D, Turner MJ, Luo Y, Zaidi SSZ, Thomas DY, Hanrahan JW. 2023 . Am J Respir Cell Mol Biol. doi: 10.1165/rcmb.2022-0241OC.

119.ÌýSaber MM, Donner J, Levade I, Acosta N, Parkins MD, Boyle B, Levesque RC, Nguyen D, Shapiro BJ. 2023 . Microb Genom.Ìý9(4). doi: 10.1099/mgen.0.000981

2022

100. Lopes-Pacheco M, Bacalhau M, Ramalho SS, Silva IAL, Ferreira FC, Carlile GW, Thomas DY, Farinha CM, Hanrahan JW, Amaral MD.Ìý2022ÌýÌýCells.Ìý11(1):136. doi: 10.3390/cells11010136.

101.ÌýAbu-Arish A, Pandžić E, Luo Y, Sato Y, Turner MJ, Wiseman PW, Hanrahan JW. 2022ÌýÌýJ Cell Sci. 135(5):jcs259002. doi: 10.1242/jcs.259002.Ìý

102.ÌýTham AC, Himdi L, Nguyen LHP, Frenkiel S, Tewfik MA. 2022ÌýÌýOTO Open.Ìý6(1):2473974X221083981. doi: 10.1177/2473974X221083981.Ìý

103.ÌýCarlile GW, Yang Q, Matthes E, Liao J, Birault V, Sneddon HF, Poole DL, Hall CJ, Hanrahan JW, Thomas DY. 2022ÌýÌýSci Rep.Ìý12(1):4595. doi: 10.1038/s41598-022-08661-8.

104.ÌýOstapska H, Le Mauff F, Gravelat FN, Snarr BD, Bamford NC, Van Loon JC, McKay G, Nguyen D, Howell PL, Sheppard DC. 2022ÌýÌýJ Fungi (Basel).Ìý8(4):336. doi: 10.3390/jof8040336.

105.ÌýGusev E, Liang F, Bhattarai S, Broering FE, Leduc-Gaudet JP, Hussain SNA, Radzioch D, Petrof B. 2022ÌýÌýAm J Physiol Regul Integr Comp Physiol.Ìý doi: 10.1152/ajpregu.00225.2021.

106. Paquette AR, Payne SR, McKay GA, Brazeau-Henrie JT, Darnowski MG, Kammili A, Bernal F, Mah TF, Gruenheid S, Nguyen D, Boddy CN. 2022 . RSC Med Chem. 13(4):445-455.

107. Bhattarai S, Li Q, Ding J, Liang F, Gusev E, Lapohos O, Fonseca GJ, Kaufmann E, Divangahi M, Petrof BJ. 2022 T. Nat Commun. 13(1):879.

108. Centorame A, Dumut DC, Youssef M, Ondra M, Kianicka I, Shah J, Paun RA, Ozdian T, Hanrahan JW, Gusev E, Petrof B, Hajduch M, Pislariu R, De Sanctis JB, Radzioch D. 2022 . Front Pharmacol. 13:876842. doi: 10.3389/fphar.2022.876842.

109. Stevers LM, Wolter M, Carlile GW, Macdonald D, Richard L, Gielkens F, Hanrahan JW, Thomas DY, Chakka SK, Peterson ML, Thomas H, Brunsveld L, Ottmann C. 2022 . Nat Commun.Ìý13(1):3586. doi: 10.1038/s41467-022-31206-6.

110. Lin N, Valiei A, McKay G, Nguyen D, Tufenkji N, Moraes C. 2022 . ACS Biomater Sci Eng. 8(7):3122-3131.

111. Valiei A, Lin N, McKay G, Nguyen D, Moraes C, Hill RJ, Tufenkji N. 2022 . ACS Appl Mater Interfaces. 14(24):27564-27574.

112. Perreault A, Harper K, Lebel M, Charbonneau M, Adam D, Brochiero E, Cantin AM, Leduc M, Gagnon L, Dubois CM. 2022 s. Am J Respir Cell Mol Biol. 67(2):164-172.

113.ÌýJomphe V, Bélanger N, Beauchamp-Parent C, Poirier C, Nasir BS, Ferraro P, Lands LC, Mailhot G. 2022 . Transplantation. 106(11):2247-2255.

114.ÌýHanrahan JW, Abu-Arish A, Wong FH, Turner MJ, Carlile GW, Thomas DY, Cantin AM. 2022 . Am J Physiol Cell Physiol. 323(5):C1374-C1392.

115.ÌýLebel M, Cliche DO, Charbonneau M, Adam D, Brochiero E, Dubois CM, Cantin AM. 2022 . Int J Mol Sci.Ìý24(1):499.

2021

88. Veltman M, De Sanctis JB, Stolarczyk M, Klymiuk N, Bähr A, Brouwer RW, Oole E, Shah J, Ozdian T, Liao J, Martini C, Radzioch D, Hanrahan JW, Scholte BJ 2021 Front Physiol. 12:619442. doi: 10.3389/fphys.2021.619442. eCollection 2021.

89. Turner MJ, Abbott-Banner K, Thomas DY, Hanrahan JW 2021 Pharmacol Ther. 224:107826. doi: 10.1016/j.pharmthera.2021.107826.

90. Hennemann LC, LaFayette SL, Malet JK, Bortolotti P, Yang T, McKay GA, Houle D, Radzioch D, Rousseau S, Nguyen D 2021 PLoS Pathog. 17(3):e1009375. doi: 10.1371/journal.ppat.1009375. eCollection 2021 Mar.

91. Kouthouridis S, Goepp J, Martini C, Matthes E, Hanrahan JW, Moraes C 2021 Integr Biol (Camb). 13(3):61-72. doi: 10.1093/intbio/zyab002.

92. Kim D, Liao J, Scales NB, Martini C, Luan X, Abu-Arish A, Robert R, Luo Y, McKay GA, Nguyen D, Tewfik MA, Poirier CD, Matouk E, Ianowski JP, Frenkiel S, Hanrahan JW 2021 J Exp Med. 218(4):e20201831. doi: 10.1084/jem.20201831.

93. Durette G, Jomphe V, Bureau NJ, Poirier C, Ferraro P, Lands LC, Mailhot G.Ìý2021ÌýÌýJ Cyst Fibros. 20(3):525-532. doi: 10.1016/j.jcf.2020.09.012.Ìý

94.ÌýVeit G, Velkov T, Xu H, Vadeboncoeur N, Bilodeau L, Matouk E, Lukacs GL. 2021ÌýÌýJ Pers Med. 11(7):643. doi: 10.3390/jpm11070643.

95.ÌýKolosova K, Gao Q, Tuznik M, Bouhabel S, Kost KM, Wang H, Li-Jessen NYK, Mongeau L, Wiseman PW. 2021ÌýÌýLaryngoscope.Ìý131(7):1578-1587. doi: 10.1002/lary.29028.Ìý

96.ÌýTurner MJ, Abbott-Banner K, Thomas DY, Hanrahan JW. 2021ÌýÌýPharmacol Ther.Ìý224:107826. doi: 10.1016/j.pharmthera.2021.107826.Ìý

97.ÌýTraboulsi H, de Souza AR, Allard B, Haidar Z, Sorin M, Moarbes V, Fixman ED, Martin JG, Eidelman DH, Baglole CJ. 2021ÌýÌýFront Physiol. 12:720196. doi: 10.3389/fphys.2021.720196. eCollection 2021.

98.ÌýSato Y, Mustafina KR, Luo Y, Martini C, Thomas DY, Wiseman PW, Hanrahan JW. 2021ÌýÌýSci Rep.Ìý11(1):23256. doi: 10.1038/s41598-021-02420-x.

99.ÌýTurner MJ, Sato Y, Thomas DY, Abbott-Banner K, Hanrahan JW. 2021ÌýÌýCell Physiol Biochem. 55(6):784-804. doi: 10.33594/000000477.

2020

72. Tan JJ, Boudreault F, Adam D, Brochiero E, Grygorczyk R 2020 Am J Physiol Lung Cell Mol Physiol. 318(1):L49-L58. doi: 10.1152/ajplung.00321.2019.

73. Garić D, De Sanctis JB, Dumut DC, Shah J, Peña MJ, Youssef M, Petrof BJ, Kopriva F, Hanrahan JW, Hajduch M, Radzioch D. 2020 Biochim Biophys Acta Mol Cell Biol Lipids. 1865(2):158538. doi: 10.1016/j.bbalip.2019.158538.

74. Baaklini I, Gonçalves CC, Lukacs GL, Young JC 2020 Sci Rep. 10(1):4176. doi: 10.1038/s41598-020-61107-x.

75. Turner MJ, Luo Y, Thomas DY, Hanrahan JW 2020 Am J Physiol Lung Cell Mol Physiol. 318(5):L908-L920. doi: 10.1152/ajplung.00285.2019.

76. Youssef M, De Sanctis JB, Shah J, Dumut DC, Hajduch M, Petrof BJ, Radzioch D 2020 Lung. 198(3):459-469. doi: 10.1007/s00408-020-00353-2.

77. Turner MJ, Luo Y, Thomas DY, Hanrahan JW 2020 Am J Physiol Lung Cell Mol Physiol. 318(5):L908-L920. doi: 10.1152/ajplung.00285.2019. Epub 2020 Mar 11.

78. Youssef M, De Sanctis JB, Shah J, Dumut DC, Hajduch M, Petrof BJ, Radzioch D 2020 Lung;198(3):459-469. doi: 10.1007/s00408-020-00353-2.

79. Crouse A, Schramm C, Emond-Rheault JG, Herod A, Kerhoas M, Rohde J, Gruenheid S, Kukavica-Ibrulj I, Boyle B, Greenwood CMT, Goodridge LD, Garduno R, Levesque RC, Malo D, Daigle F 2020 mSphere. 5(3):e00293-20. doi: 10.1128/mSphere.00293-20.

80. Emond-Rheault JG, Hamel J, Jeukens J, Freschi L, Kukavica-Ibrulj I, Boyle B, Tamber S, Malo D, Franz E, Burnett E, Daigle F, Arya G, Sanderson K, Wiedmann M, Slawson RM, Weadge JT, Stephan R, Bekal S, Gruenheid S, Goodridge LD, Levesque RC 2020 Microorganisms. 8(7):1016. doi: 10.3390/microorganisms8071016.

81. Brahimi F, Galan A, Jmaeff S, Barcelona PF, De Jay N, Dejgaard K, Young JC, Kleinman CL, Thomas DY, Saragovi HU 2020 iScience. 23(9):101447. doi: 10.1016/j.isci.2020.101447.

82. Veit G, Roldan A, Hancock MA, Da Fonte DF, Xu H, Hussein M, Frenkiel S, Matouk E, Velkov T, Lukacs GL 2020 JCI Insight. 5(18):e139983. doi: 10.1172/jci.insight.139983.

83. Centko RM, Carlile GW, Barne I, Patrick BO, Blagojevic P, Thomas DY, Andersen RJ 2020 ACS Omega. 5(40):25593-25604. doi: 10.1021/acsomega.0c02467. eCollection 2020 Oct 13.

84. Massierer D, Bourgeois N, Räkel A, Prévost K, Lands LC, Poirier C, Janaudis-Ferreira T 2020 Clin Transplant. 34(10):e14045. doi: 10.1111/ctr.14045.

85. Lopes-Pacheco M, Silva IAL, Turner MJ, Carlile GW, Sondo E, Thomas DY, Pedemonte N, Hanrahan JW, Amaral MD 2020 Biochem Pharmacol. 180:114133. doi: 10.1016/j.bcp.2020.114133.

86. Renteria AE, Mfuna Endam L, Adam D, Filali-Mouhim A, Maniakas A, Rousseau S, Brochiero E, Gallo S, Desrosiers M 2020 Am J Respir Cell Mol Biol. 63(5):707-709. doi: 10.1165/rcmb.2020-0285LE.

87. Turner MJ, Dauletbaev N, Lands LC, Hanrahan JW 2020 J Pharmacol Exp Ther.375(3):414-429. doi: 10.1124/jpet.120.000080.

2019

57. Valera FCP, Ruffin M, Adam D, Maillé É, Ibrahim B, Berube J, Rousseau S, Brochiero E, Desrosiers MY 2019 Staphylococcus aureus impairs sinonasal epithelial repair: Effects in patients with chronic rhinosinusitis with nasal polyps and control subjects. J Allergy Clin Immunol. 143(2):591-603.

58. Jeukens J, Freschi L, Kukavica-Ibrulj I, Emond-Rheault JG, Allard C, Barbeau J, Cantin A, Charette SJ, Déziel E, Malouin F, Milot J, Nguyen D, Popa C, Boyle B, Levesque RC 2019 J Clin Microbiol. 57(6):e02019-18. doi: 10.1128/JCM.02019-18.

59. Abu-Arish A, Pandžić E, Kim D, Tseng HW, Wiseman PW, Hanrahan JW 2019 J Gen Physiol. 151(6):834-849. doi: 10.1085/jgp.201812143.

60. Kim D, Huang J, Billet A, Abu-Arish A, Goepp J, Matthes E, Tewfik MA, Frenkiel S, Hanrahan JW 2019 Am J Respir Cell Mol Biol. 60(6):705-716. doi: 10.1165/rcmb.2018-0158OC.

61. Armirotti A, Tomati V, Matthes E, Veit G, Cholon DM, Phuan PW, Braccia C, Guidone D, Gentzsch M, Lukacs GL, Verkman AS, Galietta LJV, Hanrahan JW, Pedemonte N 2019 Sci Rep. 9(1):10310. doi: 10.1038/s41598-019-46639-1.

62. Rajah A, Boudreau CG, Ilie A, Wee TL, Tang K, Borisov AZ, Orlowski J, Brown CM 2019 Sci Rep. 9(1):11430. doi: 10.1038/s41598-019-47722-3.

63. Marcolefas E, Leung T, Okshevsky M, McKay G, Hignett E, Hamel J, Aguirre G, Blenner-Hassett O, Boyle B, Lévesque RC, Nguyen D, Gruenheid S, Whyte L 2019 Front Microbiol. 10:1836. doi: 10.3389/fmicb.2019.01836

64. Kim Chiaw P, Hantouche C, Wong MJH, Matthes E, Robert R, Hanrahan JW, Shrier A, Young JC 2019 PLoS One. 14(8):e0220984. doi: 10.1371/journal.pone.0220984.

65. Hanrahan JW, Sato Y, Carlile GW, Jansen G, Young JC, Thomas DY 2019 Expert Opin Ther Targets. 23(8):711-724. doi: 10.1080/14728222.2019.1628948.

66. Chandrasekaran A, Kouthouridis S, Lee W, Lin N, Ma Z, Turner MJ, Hanrahan JW, Moraes C 2019 Lab Chip. 19(17):2786-2798. doi: 10.1039/c9lc00267g.

67. Sehayek S, Gidi Y, Glembockyte V, Brandão HB, François P, Cosa G, Wiseman PW 2019 ACS Nano. 13(10):11955-11966. doi: 10.1021/acsnano.9b06033.

68. Veit G, Da Fonte DF, Avramescu RG, Premchandar A, Bagdany M, Xu H, Bensinger D, Stubba D, Schmidt B, Matouk E, Lukacs GL 2019 J Cyst Fibros. S1569-1993(19)30924-5. doi: 10.1016/j.jcf.2019.10.011.

69. Sato Y, Thomas DY, Hanrahan JW 2019 J Biol Chem. 294(48):18269-18284. doi: 10.1074/jbc.RA119.010192.

70. Jomphe V, Nguyen C, Durette G, Chagnon M, Nasir B, Poirier C, Ferraro P, Lands LC, Mailhot G 2019 Transplantation. 103(12):2614-2623. doi: 10.1097/TP.0000000000002696.

71. Millette G, Langlois JP, Brouillette E, Frost EH, Cantin AM, Malouin F 2019 Front Microbiol. 10:2880. doi: 10.3389/fmicb.2019.02880.

2018

45. Carlile GW, Yang Q, Matthes E, Liao J, Radinovic S, Miyamoto C, Robert R, Hanrahan JW, Thomas DY 2018 A novel triple combination of pharmacological chaperones improves F508del-CFTR correction. Sci Rep. 8(1):11404.

46. Kleme ML, Sané A, Garofalo C, Seidman E, Brochiero E, Berthiaume Y, Levy E 2018 CFTR Deletion Confers Mitochondrial Dysfunction and Disrupts Lipid Homeostasis in Intestinal Epithelial Cells. Nutrients. 10(7). pii: E836. doi: 10.3390/nu10070836.

47. Matthes E, Goepp J, Martini C, Shan J, Liao J, Thomas DY, Hanrahan JW 2018 Variable Responses to CFTR Correctors in vitro: Estimating the Design Effect in Precision Medicine. Front Pharmacol. 19;9:1490.

48. Matthes E, Hanrahan JW, Cantin AM 2018 F508del-CFTR is not corrected by thymosin α1. Nat Med. 24(7):890-891.

49. Ménade M, Kozlov G, Trempe JF, Pande H, Shenker S, Wickremasinghe S, Li X, Hojjat H, Dicaire MJ, Brais B, McPherson PS, Wong MJH, Young JC, Gehring K 2018 Structures of ubiquitin-like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations. J Biol Chem. 293(33):12832-12842.

50. Mottawea W, Duceppe MO, Dupras AA, Usongo V, Jeukens J, Freschi L, Emond-Rheault JG, Hamel J, Kukavica-Ibrulj I, Boyle B, Gill A, Burnett E, Franz E, Arya G, Weadge JT, Gruenheid S, Wiedmann M, Huang H, Daigle F, Moineau S, Bekal S, Levesque RC, Goodridge LD, Ogunremi D 2018 Salmonella enterica Prophage Sequence Profiles Reflect Genome Diversity and Can Be Used for High Discrimination Subtyping. Front Microbiol. 9:836. doi: 10.3389/fmicb.2018.00836. eCollection 2018.

51. Pandžić E, Abu-Arish A, Whan RM, Hanrahan JW, Wiseman PW 2018 Velocity landscape correlation resolves multiple flowing protein populations from fluorescence image time series. Methods. 140-141:126-139

52. Ruffin M, Roussel L, Maillé É, Rousseau S, Brochiero E 2018 Vx-809/Vx-770 treatment reduces inflammatory response to Pseudomonas aeruginosa in primary differentiated cystic fibrosis bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 314(4):L635-L641.

53. Sauvé V, Sung G, Soya N, Kozlov G, Blaimschein N, Miotto LS, Trempe JF, Lukacs GL, Gehring K 2018 Mechanism of parkin activation by phosphorylation. Nat Struct Mol Biol. 25(7):623-630. Erratum in: Nat Struct Mol Biol. 2018 Aug;25(8):744

54. Sauvé V, Sung G, Soya N, Kozlov G, Blaimschein N, Miotto LS, Trempe JF, Lukacs GL, Gehring K 2018 Publisher Correction: Mechanism of parkin activation by phosphorylation. Nat Struct Mol Biol. 25(8):744.

55. Veit G, Xu H, Dreano E, Avramescu RG, Bagdany M, Beitel LK, Roldan A, Hancock MA, Lay C, Li W, Morin K, Gao S, Mak PA, Ainscow E, Orth AP, McNamara P, Edelman A, Frenkiel S, Matouk E, Sermet-Gaudelus I, Barnes WG, Lukacs GL 2018 Structure-guided combination therapy to potently improve the function of mutant CFTRs. Nat Med. 24(11):1732-1742.

56. Wong FH, AbuArish A, Matthes E, Turner MJ, Greene LE, Cloutier A, Robert R, Thomas DY, Cosa G, Cantin AM, Hanrahan JW 2018 Cigarette smoke activates CFTR through ROS-stimulated cAMP signaling in human bronchial epithelial cells. Am J Physiol Cell Physiol. 314(1):C118-C134.

2017

34. Avramescu RG, Kai Y, Xu H, Bidaud-Meynard A, Schnúr A, Frenkiel S, Matouk E, Veit G, Lukacs GL 2017 Mutation-specific downregulation of CFTR2 variants by gating potentiators. Hum Mol Genet. 26(24):4873-4885.

35. Bagdany M, Veit G, Fukuda R, Avramescu RG, Okiyoneda T, Baaklini I, Singh J, Sovak G, Xu H, Apaja PM, Sattin S, Beitel LK, Roldan A, Colombo G, Balch W, Young JC, Lukacs GL 2017 Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell. Nat Commun. 8(1):398.

36. Calles-Garcia D, Yang M, Soya N, Melero R, Ménade M, Ito Y, Vargas J, Lukacs GL, Kollman JM, Kozlov G, Gehring K 2017 Single-particle electron microscopy structure of UDP-glucose:glycoprotein glucosyltransferase suggests a selectivity mechanism for misfolded proteins. J Biol Chem. 292(27):11499-11507.

37. Cantin AM, Hanrahan JW 2017 Thymosin α1: a single drug with multiple targets in cystic fibrosis. Nat Med. 23(5):536-538.

38. Garić D, De Sanctis JB, Wojewodka G, Houle D, Cupri S, Abu-Arish A, Hanrahan JW, Hajduch M, Matouk E, Radzioch D 2017 Fenretinide differentially modulates the levels of long- and very long-chain ceramides by
downregulating Cers5 enzyme: evidence from bench to bedside. J Mol Med (Berl). 95(10):1053-1064.

39. Hanrahan JW, Matthes E, Carlile G, Thomas DY 2017 Corrector combination therapies for F508del-CFTR. Curr Opin Pharmacol. 34:105-111. doi: 10.1016/j.coph.2017.09.016. Review.

40. Hariri AA, Hamblin GD, Hardwick JS, Godin R, Desjardins JF, Wiseman PW, Sleiman HF, Cosa G 2017 Stoichiometry and Dispersity of DNA Nanostructures Using Photobleaching Pair-Correlation Analysis. Bioconjug Chem. 28(9):2340-2349.

41. Maillé É, Ruffin M, Adam D, Messaoud H, Lafayette SL, McKay G, Nguyen D, Brochiero E 2017 Quorum Sensing Down-Regulation Counteracts the Negative Impact of Pseudomonas aeruginosa on CFTR Channel Expression, Function and Rescue in Human Airway Epithelial Cells. Front Cell Infect Microbiol. 7:470.

42. Mizutani M, Bérubé J, Ahlgren HG, Bernier J, Matouk E, Nguyen D, Rousseau S 2017 Corticosteroid-resistant inflammatory signalling in Pseudomonas-infected bronchial cells. ERJ Open Res. 3(2). pii: 00144-2016.

43. Rammal A, Tewfik M, Rousseau S 2017 Differences in RANTES and IL-6 levels among chronic rhinosinusitis patients with predominant gram-negative and gram-positive infection. J Otolaryngol Head Neck Surg. 46(1):7.

44. Requena S, Ponomarchuk O, Castillo M, Rebik J, Brochiero E, Borejdo J, Gryczynski I, Dzyuba SV, Gryczynski Z, Grygorczyk R, Fudala R 2017 Imaging viscosity of intragranular mucin matrix in cystic fibrosis cells. Sci Rep. 7(1):16761.

2016

19. Bilodeau C, Bardou O, Maillé É, Berthiaume Y, Brochiero E 2016 Deleterious impact of hyperglycemia on cystic fibrosis airway ion transport and epithelial repair. J Cyst Fibros. 15(1):43-51.

20. Boisvert AA, Cheng MP, Sheppard DC, Nguyen D 2016 Microbial Biofilms in Pulmonary and Critical Care Diseases. Ann Am Thorac Soc. [Epub ahead of print]

21. Carlile GW, Robert R, Matthes E, Yang Q, Solari R, Hatley R, Edge CM, Hanrahan JW, Andersen R, Thomas DY, Birault V 2016 Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity. Mol Pharmacol. 90(2):65-79.

22. Foo B, Williamson B, Young JC, Lukacs G, Shrier A 2016 hERG quality control and the long QT syndrome. J Physiol. 594(9):2469-81.

23. Furuya K, Tan JJ, Boudreault F, Sokabe M, Berthiaume Y, Grygorczyk R 2016 Real-time imaging of inflation-induced ATP release in the ex vivo rat lung. Am J Physiol Lung Cell Mol Physiol. 311(5):L956-L969.

24. Ilie A, Gao AY, Reid J, Boucher A, McEwan C, Barrière H, Lukacs GL, McKinney RA, Orlowski J 2016 A Christianson syndrome-linked deletion mutation (Δ(287)ES(288)) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death. Mol Neurodegener. 11(1):63. doi: 10.1186/s13024-016-0129-9

25. Klein H, Abu-Arish A, Trinh NT, Luo Y, Wiseman PW, Hanrahan JW, Brochiero E, Sauvé R 2016 Investigating CFTR and KCa3.1 Protein/Protein Interactions. PLoS One. 11(4):e0153665.

26. Matthes E, Goepp J, Carlile GW, Luo Y, Dejgaard K, Billet A, Robert R, Thomas DY, Hanrahan JW 2016 Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor). Br J Pharmacol. 173(3):459-70.

27. Matouk E, Nguyen D, Benedetti A, Bernier J, Gruber J, Landry J, Rousseau S, Ahlgren HG, Lands LC, Wojewodka G, Radzioch D 2016 C-Reactive Protein in Stable Cystic Fibrosis: An Additional Indicator of Clinical Disease Activity and Risk of Future Pulmonary Exacerbations. J Pulm Respir Med. 6(5):1000375.

28. Ntimbane T, Mailhot G, Spahis S, Rabasa-Lhoret R, Kleme ML, Melloul D, Brochiero E, Berthiaume Y, Levy E 2016 CFTR silencing in pancreatic β-cells reveals a functional impact on glucose-stimulated insulin secretion and oxidative stress response. Am J Physiol Endocrinol Metab. 310(3):E200-12.

29. Roussel L, LaFayette S, Nguyen D, Baglole CJ, Rousseau S 2016 Differential Contribution of the Aryl-Hydrocarbon Receptor and Toll-Like Receptor Pathways to IL-8 Expression in Normal and Cystic Fibrosis Airway Epithelial Cells Exposed to Pseudomonas aeruginosa. Front Cell Dev Biol. 4:148.

30. Ruffin M, Bilodeau C, Maillé É, LaFayette SL, McKay GA, Trinh NT, Beaudoin T, Desrosiers MY, Rousseau S, Nguyen D, Brochiero E 2016 Quorum-sensing inhibition abrogates the deleterious impact of Pseudomonas aeruginosa on airway epithelial repair. FASEB J. pii: fj.201500166R.

31. Saliba J, Fnais N, Tomaszewski M, Carriere JS, Frenkiel S, Frasnelli J, Tewfik MA 2016 The role of trigeminal function in the sensation of nasal obstruction in chronic rhinosinusitis. Laryngoscope. 126(5):E174-8.

32. Schnúr A, Hegyi P, Rousseau S, Lukacs GL, Veit G 2016 Epithelial Anion Transport as Modulator of Chemokine Signaling. Mediators Inflamm. 2016:7596531.

33. Turner MJ, Matthes E, Billet A, Ferguson AJ, Thomas DY, Randell SH, Ostrowski LE, Abbott-Banner K, Hanrahan JW 2016 The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia. Am J Physiol Lung Cell Mol Physiol. 310(1):L59-70.

2015

6. Abu-Arish A, Pandzic E, Goepp J, Matthes E, Hanrahan JW, Wiseman PW 2015 Cholesterol modulates CFTR confinement in the plasma membrane of primary epithelial cells. Biophys J. 109(1):85-94.

7. Ahlgren HG, Benedetti A, Landry JS, Bernier J, Matouk E, Radzioch D, Lands LC, Rousseau S, Nguyen D 2015 Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients. BMC Pulm Med. 15:67.

8. Carlile GW, Robert R, Goepp J, Matthes E, Liao J, Kus B, Macknight SD, Rotin D, Hanrahan JW, Thomas DY 2015 Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking. J Cyst Fibros. 14(1):16-25.

9. Chekabab SM, Silverman RJ, Lafayette SL, Luo Y, Rousseau S, Nguyen D 2015 Staphylococcus aureus Inhibits IL-8 Responses Induced by Pseudomonas aeruginosa in Airway Epithelial Cells. PLoS One. 10(9):e0137753.

10. Dauletbaev N, Das M, Cammisano M, Chen H, Singh S, Kooi C, Leigh R, Beaudoin T, Rousseau S, Lands LC 2015 Rhinovirus Load Is High despite Preserved Interferon-β Response in Cystic Fibrosis Bronchial Epithelial Cells. PLoS One. 10(11):e0143129.

11. Dauletbaev N, Herscovitch K, Das M, Chen H, Bernier J, Matouk E, Bérubé J, Rousseau S, Lands LC 2015 Down-regulation of IL-8 by high-dose vitamin D is specific to hyperinflammatory macrophages and involves mechanisms beyond up-regulation of DUSP1. Br J Pharmacol. 172(19):4757-71.

12. Freschi L, Jeukens J, Kukavica-Ibrulj I, Boyle B, Dupont MJ, Laroche J, Larose S, Maaroufi H, Fothergill JL, Moore M, Winsor GL, Aaron SD, Barbeau J, Bell SC, Burns JL, Camara M, Cantin A, Charette SJ, Dewar K, Déziel É, Grimwood K, Hancock RE, Harrison JJ, Heeb S, Jelsbak L, Jia B, Kenna DT, Kidd TJ, Klockgether J, Lam JS, Lamont IL, Lewenza S, Loman N, Malouin F, Manos J, McArthur AG, McKeown J, Milot J, Naghra H, Nguyen D, Pereira SK, Perron GG, Pirnay JP, Rainey PB, Rousseau S, Santos PM, Stephenson A, Taylor V, Turton JF, Waglechner N, Williams P, Thrane SW, Wright GD, Brinkman FS, Tucker NP, Tümmler B, Winstanley C, Levesque RC 2015 Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium. Front Microbiol. 6:1036.

13. Girault A, Chebli J, Privé A, Trinh NT, Maillé E, Grygorczyk R, Brochiero E 2015 Complementary roles of KCa3.1 channels and β1-integrin during alveolar epithelial repair. Respir Res. 16:100.

14. Jeukens J, Freschi L, Kukavica-Ibrulj I, Nguyen D, Levesque RC 2015 Draft Genome Sequence of Triclosan-Resistant Cystic Fibrosis Isolate Achromobacter xylosoxidans CF304. Genome Announc. 3(4). pii: e00865-15.

15. LaFayette SL, Houle D, Beaudoin T, Wojewodka G, Radzioch D, Hoffman LR, Burns JL, Dandekar AA, Smalley NE, Chandler JR, Zlosnik JE, Speert DP, Bernier J, Matouk E, Brochiero E, Rousseau S, Nguyen D 2015 Cystic fibrosis-adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses. Sci Adv. 1(6). pii: e1500199.

16. McGovern TK, Goldberger M, Allard B, Farahnak S, Hamamoto Y, O'Sullivan M, Hirota N, Martel G, Rousseau S, Martin JG 2015 Neutrophils mediate airway hyperresponsiveness after chlorine-induced airway injury in the mouse. Am J Respir Cell Mol Biol. 52(4):513-22.

17. Trinh NT, Bilodeau C, Maillé É, Ruffin M, Quintal MC, Desrosiers MY, Rousseau S, Brochiero E 2015 Deleterious impact of Pseudomonas aeruginosa on cystic fibrosis transmembrane conductance regulator function and rescue in airway epithelial cells. Eur Respir J. 45(6):1590-602.

18. Urb M, Snarr BD, Wojewodka G, Lehoux M, Lee MJ, Ralph B, Divangahi M, King IL, McGovern TK, Martin JG, Fraser R, Radzioch D, Sheppard DC 2015 Evolution of the Immune Response to Chronic Airway Colonization with Aspergillus fumigatus Hyphae. Infect Immun. 83(9):3590-600.

2014

1. Al-Alwan LA, Chang Y, Rousseau S, Martin JG, Eidelman DH, Hamid Q 2014 CXCL1 inhibits airway smooth muscle cell migration through the decoy receptor Duffy antigen receptor for chemokines. J Immunol. 193(3):1416-26.

2. Jaworska J, Coulombe F, Downey J, Tzelepis F, Shalaby K, Tattoli I, Berube J, Rousseau S, Martin JG, Girardin SE, McCullers JA, Divangahi M 2014 NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein. Proc Natl Acad Sci USA. 111(20):E2110-9.

3. Varshney R, Frenkiel S, Nguyen LH, Young M, Del Maestro R, Zeitouni A, Tewfik MA; National Research Council Canada 2014 Development of the Ã山ǿ¼é simulator for endoscopic sinus surgery: a new high-fidelity virtual reality simulator for endoscopic sinus surgery. Am J Rhinol Allergy. 28(4):330-4.

4. Varshney R, Frenkiel S, Nguyen LH, Young M, Del Maestro R, Zeitouni A, Saad E, Funnell WR; National Research Council Canada, Tewfik MA 2014 The Ã山ǿ¼é simulator for endoscopic sinus surgery (MSESS): a validation study. J Otolaryngol Head Neck Surg. 43:40.

5. Wojewodka G, De Sanctis JB, Bernier J, Bérubé J, Ahlgren HG, Gruber J, Landry J, Lands LC, Nguyen D, Rousseau S, Benedetti A, Matouk E, Radzioch D 2014 Candidate markers associated with the probability of future pulmonary exacerbations in cystic fibrosis patients. PLoS One. 9(2):e88567.

Supported by:

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Ã山ǿ¼é is situated on the traditional territory of the Kanien’kehà:ka, a place which has long served as a site of meeting and exchange amongst nations. We recognize and respect the Kanien’kehà:ka as the traditional custodians of these lands and waters.

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