You are what your father eats
The research focused on vitamin B9, also called folate, which is found in a range of green leafy vegetables, cereals, fruit and meats. It is well known that in order to prevent miscarriages and birth defects mothers need to get adequate amounts of folate in their diet. But the way that a father鈥檚 diet can influence the health and development of their offspring has received almost no attention. Now research from the Kimmins group shows for the first time that the father鈥檚 folate levels may be just as important to the development and health of their offspring as are those of the mother. Indeed, the study suggests that fathers should pay as much attention to their lifestyle and diet before they set out to conceive a child as mothers do.
鈥淒espite the fact that folic acid is now added to a variety of foods, fathers who are eating high-fat, fast food diets or who are obese may not be able to use or听 metabolize folate in the same way as those with adequate levels of the vitamin,鈥� says Kimmins. 鈥淧eople who live in the Canadian North or in other parts of the world where there is food insecurity may also be particularly at risk for folate deficiency. And we now know that this information will be passed on from the father to the embryo with consequences that may be quite serious.鈥�
The researchers arrived at this conclusion by working with mice, and comparing the offspring of fathers with insufficient folate in their diets with the offspring of fathers whose diets contained sufficient levels of the vitamin. They found that paternal folate deficiency was associated with an increase in birth defects of various kinds in the offspring, compared to the offspring of mice whose fathers were fed a diet with sufficient folate.
鈥淲e were very surprised to see that there was an almost 30 per cent increase in birth defects in the litters sired by听 fathers whose levels of folates were insufficient,鈥� said Dr. Romain Lambrot, of 缅北强奸鈥檚 Dept. of Animal Science, one of the researchers who worked on the study. 鈥淲e saw some pretty severe skeletal abnormalities that included both cranio-facial and spinal deformities.鈥澨�
The research from the Kimmins鈥� group shows that there are regions of the sperm epigenome that are sensitive to life experience and particularly to diet. And that this information is in turn transferred to a so-called epigenomic map that influences development and may also influence metabolism and disease in the offspring in the long-term. (The epigenome is like a switch, which is affected by environmental cues, and is involved in many diseases including cancer and diabetes. The epigenome influences the way that genes are turned on or off, and hence how heritable information gets passed along).
Although it has been known for some time that there is a massive erasure and re-establishment that takes place in the epigenome as the sperm develops, this study now shows that along with the developmental map, the sperm also carries a memory of the father鈥檚 environment and possibly even of his diet and lifestyle choices.
鈥淥ur research suggests that fathers need to think about what they put in their mouths, what they smoke and what they drink and remember they are caretakers of generations to come,鈥� said Kimmins. 鈥淚f all goes as we hope, our next step will be to work with collaborators at a fertility clinic so that we can start assessing the links in men between diet, being overweight and how this information relates to the health of their children.鈥�
The Pilot projects program of Genome Quebec was an important donor to the Kimmins research. Additional funding for the research came from the Natural Sciences and Research Council of Canada (NSERC), the Canadian Institute of Health Research (CIHR) and the R茅seau Qu茅b茅cois en reproduction (Fonds qu茅b茅cois de la recherche sur la nature et les technologies).
To read the full article,鈥滾ow paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes,鈥� by R. Lambrot, C.Xu, S. Saint-Phar, G. Chountalos, T. Cohen, M. Paquet, M. Suderman, M. Hallett, and S. Kimmins in Nature Communications:
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