Games for science
Scientists are using video games to tap the collective intelligence of people around the world, while doctors and educators are turning to games to treat and teach. [鈥 鈥淢SA is probably one of the most important tools in bioinformatics today,鈥� says J茅r么me Waldisp眉hl, a bioinformatician at 缅北强奸 in Montreal, Canada. But the computer algorithms employed to perform MSA don鈥檛 guarantee perfect accuracy, so Waldisp眉hl and colleagues created Phylo 鈥� an online game that transforms the MSA problem into a simple puzzle that anyone can play. The aim of the game is to improve the sequence alignments of the promoter regions of hundreds of disease-related genes from 44 vertebrate species. The sequences are presented as several rows of blocks, color-coded to represent the four bases of DNA, and players shift the sequences left or right in order to find the best possible match for up to eight different species at a time. Within 7 months of its November 2010 release, Phylo had more than 12,000 registered users and 3,000 regular players. And they鈥檝e proven themselves worthy: 70 percent of the roughly 350,000 MSA solutions generated by the Phylo community are more accurate than those generated by the best computer algorithm (PLOS ONE, 7:e31362, 2012). 鈥淭he results returned by the players were much better than what we hoped for,鈥� says Waldisp眉hl. 鈥淭he human brain has evolved to be very good at recognizing visual patterns, and we can benefit from that.鈥� 鈥�
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