缅北强奸

Accelerating drug discovery with Open Science

The Neuro's drug discovery initiative supports research by developing assays shared with the scientific community

In the past 40 years, the model of drug discovery used by the pharmaceutical industry, while proving successful for some applications, has produced very little for neurodegenerative diseases.

鈥淭ake Parkinson鈥檚 disease, for instance: there have been zero new disease modifying medications developed in the last 40 years, despite hundreds of millions of dollars being invested in research,鈥 says Dr. Edward Fon, whose lab focuses on molecular and cellular research into Parkinson鈥檚 disease. 鈥淲e have to ask if there is a better way to find therapies that will modify the course of diseases, slowing or stopping them from progressing. While Open Science is not going to solve every problem, it will be a big part of the solution.鈥

The Neuro's drug discovery initiative aims to support research by developing assays that investigate different aspects of target cells and sharing these assays with colleagues around the world. The main vehicle for sharing assays is The Neuro鈥檚 Induced Pluripotent Stem Cell (iPSC) platform, developed recently with seed money generously donated by Sebastian van Berkom and Ghislaine Saucier.

鈥淲e can provide industry-standard assays researchers can use to test compounds,鈥 says Thomas Durcan, another Parkinson鈥檚 researcher who manages the iPSC platform. 鈥淚n collaboration with researchers at Universit茅 Laval, we reprogram blood cells from patients with neurological diseases into stem cells, and then transform the stem cells into the type of neural cells most impacted in neuropathology.鈥

This gives researchers the ability to compare normal and diseased states of the cells within one patient, which has long been possible for some diseases but is a novel advance for neurological research. The Centre for Drug Research and Development, a Canadian nonprofit organization that aims to speed the translation of discoveries into therapies, and the international Structural Genomics Consortium have both formed partnerships with the Tanenbaum Open Science Institute to use the iPSC platform.

鈥淚f we can identify potential compounds for targeting diseases such as Parkinson鈥檚 and share them so they can be screened and tested throughout the scientific community, we can accelerate the rate of discovery,鈥 says Dr. Fon. 鈥淥ther researchers can benefit from the resources we develop, and the chances of 100 laboratories finding something useful is much greater than that of one lab working alone. If we can come up with something leading to treatment for Parkinson鈥檚 disease, that would be an incredible payback.鈥

Related links:
Induced Pluripotent Stem Cell (iPSC) platform
Centre for Drug Research and Development
Structural Genomics Consortium

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The Neuro (Montreal Neurological Institute-Hospital)听is a bilingual academic healthcare institution. We are a听缅北强奸 research and teaching institute; delivering high-quality patient care, as part of the Neuroscience Mission of the 缅北强奸 Health Centre.听We are听proud to be a Killam Institution, supported by the Killam Trusts.

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