Event
PhD Oral Defense: In-Silico Structural and Functional Analysis of Trypanosoma brucei RNA Editing Ligases and their Interaction with their Binding Partner Proteins
Thursday, April 2, 2015 15:00
Parasitology Building
P-117, 21111 Lakeshore Road, St Anne de Bellevue, QC, H9X 3V9, CA
PhD Oral Defense of Alireza Darissi Shaneh, Institute of Parasitology
RNA editing is a post-transcriptional modification in which a base is substituted by another one or inserted or deleted. In trypanosomatids, RNA editing is carried out by uridine insertion or deletion. A multiprotein complex, the editosome, trims the mitochondrial mRNA transcripts, and it consists of twenty know proteins out of which kinetoplastid RNA editing ligases 1 and 2 (KREL1 and KREL2) were subjects of this study.