Djavad Mowafaghian Foundation shares The Neuro鈥檚 open science vision to accelerate drug discovery and find new and effective treatments for autism spectrum disorders
Abnormalities shown to first appear in brain networks involved in sensory processing
The origins of autism remain mysterious. What areas of the brain are involved, and when do the first signs appear? New findings published in brings us closer to understanding the pathology of autism, and the point at which it begins to take shape in the human brain. Such knowledge will allow earlier interventions in the future and better outcomes for autistic children.
Researchers from 缅北强奸 and the University of Montreal have identified a crucial link between protein synthesis and autism spectrum disorders (ASD), which can bolster new therapeutic avenues. Regulation of protein synthesis, also termed mRNA translation, is the process by which cells manufacture proteins. This mechanism is involved in all aspects of cell and organism function. A new study in mice has found that abnormally high synthesis of a group of neuronal proteins called neuroligins results in symptoms similar to those diagnosed in ASD. The study also reveals that autism-like behaviors can be rectified in adult mice with compounds inhibiting protein synthesis, or with gene-therapy targeting neuroligins. Their results are published in the journal聽Nature.