A new paper published today.

webfull — Tue, 20 Jun 2023 21:21:52 +0000

A new paper from my lab is now published online in a Nature paper Today. (Writes Parisa Ariya)

Published: 20 June 2023

The Tsantrizos and Berghuis groups unravel important mechanistic insight into metabolic regulation/dysregulation with important implications for the treatment of cancer

webfull — Sat, 21 Jan 2017 18:34:41 +0000

Human farnesyl pyrophosphate synthase (hFPPS) plays a key role in the prenylation of small GTPases, such as RAS and RAP 1A, which are intimately involved in oncogenesis. An allosteric pocket of the enzyme has been of particular interest as a therapeutic target, however, its natural biological function has been (until now) unknown. The teams of Berghuis (Biochemistry) and Tsantrizos (Chemistry) have just reported that the catalytic product of hFPPS, farnesyl pyrophosphate (FPP), bind to this pocket and locks the enzyme in a conformationally inactive state.

Published: 21 January 2017

�山ǿ�� News - Article

A new paper published today.

The Tsantrizos and Berghuis groups unravel important mechanistic insight into metabolic regulation/dysregulation with important implications for the treatment of cancer