Dr St茅phane Richard (LDI) -
Dr. Stephane Richard
Lady Davis Institute, Associate Director
James 缅北强奸 Professor of Medicine & Oncology
聽"Arginine methylation and QUAKING as regulators of CNS myelination"
础叠厂罢搁础颁罢:听
Our laboratory studies the family of proteins termed QUAKING and arginine methyltransferases (PRMTs) in myelination. These proteins are essentially master regulators of oligodendrocyte function and we have shown that the absence of these proteins causes myelination defects (quaking phenotype) in mice. By understanding how the quaking proteins and the PRMTs function, we are able to tease out the molecular details about how oligodendrocytes become mature and produce myelin. This information will be important for the basic understanding of myelination and with possible implications for re-myelination therapies.